Imipramine longitudinal data

Source

Reisby, N., Gram, L.F., Bech, P. et al. Imipramine: Clinical effects and pharmacokinetic variability. Psychopharmacology 54, 263-272 (1977).

Value

riesby: a tibble

Details

These data are from a longitudinal clinical trial for depression. The outcome is the change in depression scores week-to-week. The endogenous column is an indicator for whether the subject fit the WHO Depression Scale classification of endogenous. The imipramine and desipramine columns are measurements of plasma levels for both substances.

Examples

data(riesby)
str(riesby)
#> tibble [250 × 7] (S3: tbl_df/tbl/data.frame)
#>  $ subject    : Factor w/ 66 levels "101","103","104",..: 1 1 1 1 2 2 2 2 3 3 ...
#>  $ depr_score : num [1:250] -8 -19 -22 -23 -18 -9 -18 -20 -11 -16 ...
#>  $ week       : num [1:250] 0 1 2 3 0 1 2 3 0 1 ...
#>  $ male       : num [1:250] 0 0 0 0 1 1 1 1 1 1 ...
#>  $ endogenous : num [1:250] 0 0 0 0 0 0 0 0 1 1 ...
#>  $ imipramine : num [1:250] 4.04 3.93 4.33 4.37 2.77 ...
#>  $ desipramine: num [1:250] 4.2 4.81 4.96 4.96 5.24 ...